IGF-1 LR3 is a research peptide supplied by Badger Compounds for laboratory use only and is not intended for human or animal consumption.

IGF-1 LR3 Peptide

Overview

IGF-1 LR3 is a synthetic analog of insulin-like growth factor 1 (IGF-1) offered by Badger Compounds as a research compound for laboratory use only. This 83-amino-acid peptide is studied widely in cellular signaling, growth factor, and receptor biology investigations.

The molecule combines a 13-amino-acid N-terminal extension with an arginine substitution at position 3 of the native IGF-1 sequence. These modifications reduce its affinity for insulin-like growth factor binding proteins (IGFBPs), a property that has made it a frequently selected tool in laboratory models.

Because of this reduced binding protein interaction, IGF-1 LR3 demonstrates extended activity in many in vitro systems compared with native IGF-1. Researchers commonly incorporate it into cell culture protocols where a stable, long-acting growth factor signal is required.

Every lot of IGF-1 LR3 from Badger Compounds is characterized to a purity of ≥99% (HPLC) and verified by third-party analytical testing, supporting consistent and reproducible experimental conditions.

IGF-1 LR3 Peptide Receptor Interaction Research Context

In published research models, IGF-1 LR3 binds the type 1 IGF receptor (IGF-1R), a receptor tyrosine kinase expressed across many cell types. Receptor engagement initiates autophosphorylation and downstream activation of intracellular signaling cascades.

Two pathways are most frequently described in the literature: the PI3K/Akt axis, associated with cell survival and metabolic signaling, and the Ras/MAPK axis, associated with proliferative responses. The reduced IGFBP affinity of IGF-1 LR3 means a greater fraction remains available to interact with the receptor in culture, which researchers note when designing dose-response studies. All such observations are limited to controlled laboratory settings.

Additional Research Considerations

Investigators evaluating this compound often review the broader IGF-1 literature to contextualize their findings. A current overview of relevant publications can be found through the PubMed database, which indexes peer-reviewed studies describing IGF-1 analogs in experimental systems.

Research Applications

• Investigation of IGF-1 receptor signaling and downstream pathway activation in cultured cells
• Comparative studies of growth factor stability and binding protein interactions
• Cell proliferation and differentiation models in controlled laboratory environments
• Reference standard work alongside native IGF-1 and related analogs
• Method development for analytical detection of growth factor peptides

Product Specifications

• Form: Lyophilized powder
• Purity: ≥99% (HPLC)
• Quantity: 1 mg per vial
• Molecular Weight: 9,111 Da
• CAS Number: 946870-92-4
• Solubility: Soluble in compatible aqueous buffers
• Characterization: Identity and purity confirmed by HPLC and mass spectrometry
• Testing: Independent third-party analytical verification

Storage and Handling

Lyophilized IGF-1 LR3 should be stored at -20°C and protected from light and moisture. Once reconstituted in a laboratory setting, the solution is best kept refrigerated at 2°C to 8°C and used within a short working window. Handling should follow standard laboratory safety practices, including the use of appropriate personal protective equipment. This material is intended for qualified research personnel only.

Related Research Compounds

Laboratories studying growth factor and secretagogue pathways frequently pair IGF-1 LR3 with related research peptides such as CJC-1295 (No DAC), Sermorelin, and AOD-9604. Browse the full research peptides catalog for additional compounds.

Frequently Asked Questions

What is IGF-1 LR3?
IGF-1 LR3 is a long-acting synthetic analog of insulin-like growth factor 1, modified to reduce binding protein affinity. It is supplied strictly as a research compound for laboratory use.

What purity is this IGF-1 LR3?
Each lot is characterized to ≥99% (HPLC) purity and confirmed through independent third-party testing.

How should IGF-1 LR3 be stored?
Store the lyophilized powder at -20°C away from light and moisture, and refrigerate any reconstituted solution prepared in the laboratory.

Disclaimer

This product is intended for laboratory and research use only. It is not a drug, food, cosmetic, or dietary supplement, and it is not intended to diagnose, treat, cure, or prevent any disease. It is not for human or veterinary use or consumption in any form. All information provided is for educational and research purposes only and does not constitute medical advice. By purchasing, the buyer confirms they are a qualified researcher or institution and accepts full responsibility for safe handling, use, and disposal in compliance with applicable laws and regulations.